Jarvis Edwin Seegmiller, MD, 1920-2006

Edwin Clarke, MD, FRCP (1919-1996).

Alexander Leaf, MD (1920–2012)—A tribute to a life in physiology and medicine

It is with deep sorrow that I announce the recent passing of Dr. Alexander Leaf (Figure 1), one of the giants in cardio-renal physiology and medicine. After a short illness, Dr. Leaf died peacefully at his home in Concord, MA on December 24, 2012 at the age of 92 years. Those of us who worked with Alex can personally testify to his sense of humor, his humility, his enthusiasm for research, and ...

Jarvis Voice Controlled Devices

Jarvis is a system designed to respond to user issued commands to provide convenient control over a number of electronic devices. These devices can be lights, TV's, radios, stereos, etc. The system will be designed to work best within a moderate home with the convenience of a wireless router. Fig. 1.1 shows how each stage of the system will interact with each other. More details on this are pro...

Partial HPRT deficiency (Kelley-Seegmiller syndrome).

Hypoxanthine-guanine phosphoribosyl transferase (HPRT) deficiency is an X-linked defect of purine metabolism. Clinical manifestations are usually related to the degree of enzyme deficiency; complete HPRT deficiency (Lesh-Nyhan Syndrome) presenting with severe neurological or renal symptoms, or partial HPRT deficiency (Kelley-Seegmiller syndrome) manifesting as a gout-urolithiasis syndrome. We r...

Alj Edwin Milgrom

binding site of the AFP gene promoter in one (2 ). AFP is a widely used tumor marker. Although HPAFP is a rare disorder, it needs to be considered and differentiated from tumors to avoid inappropriate explorations and treatment decisions. We present a simple test based on restriction fragment length polymorphism (RFLP) analysis for screening of HPAFP mutations. This test can be used in patients...